HCV-associated lymphomas.

Massimo Fiorilli; Cristina Mecucci; Patrizia Farci; Milvia Casato

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PubMed · 15129650

HCV-associated lymphomas.

Massimo Fiorilli·Cristina Mecucci·Patrizia Farci·Milvia Casato

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Abstract

Epidemiologic and molecular observations have recently suggested that hepatitis C virus (HCV) may be the causative agent of some B-cell non-Hodgkin lymphomas (B-NHL). Epidemiologic data suggest that in Italy about 5% of B-NHL are caused by HCV. Molecular data indicate a close relationship between HCV-associated B-NHL and type II mixed cryoglobulinemia. The latter disorder appears to reflect the benign monoclonal proliferation of B cells expressing a specific cross-reactive idiotype, known as WA, that may recognize an antigen of HCV, perhaps the E2 protein. Genetic abnormalities occurring during this phase of antigen-induced clonal expansion may drive the neoplastic transformation into low- or high-grade lymphoma. The recent demonstration that splenic B cell lymphomas associated with HCV-infection may regress after successful antiviral therapy confirms a role for this virus in B-cell lymphomagenesis.

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Antineoplastic Agents Antiviral Agents B-Lymphocytes Cell Transformation, Viral Chromosome Aberrations Cryoglobulinemia Disease Progression Forecasting Genes, bcl-2 Hepacivirus Hepatitis C Humans Lymphoma, B-Cell Lymphoproliferative Disorders Models, Biological Comment Journal Article Research Support, Non-U.S. Gov't Review

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Massimo Fiorilli, Cristina Mecucci, Patrizia Farci, Milvia Casato. 2003. HCV-associated lymphomas.. https://pubmed.ncbi.nlm.nih.gov/15129650/

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