[Stimulation of the delta 1-receptors help to decrease reperfusion induced myocardial stunning].

L N Maslov; Iu B Lishmanov

PubMed · 15131985

[Stimulation of the delta 1-receptors help to decrease reperfusion induced myocardial stunning].

Abstract

In vivo or in vitro administration of a omega 1 receptor agonist d-SKF 10,047 (1 mg/kg intravenously or 10 mg/l in vitro) promoted an increase in the resistance of isolated perfused rat heart to ischemia/reperfusion injury. Both in vivo and in vitro stimulation of omega receptors prevents development of reperfusion contracture and release of creatine kinase and increases the developed pressure, double product, +dP/dt, and -dP/dt in the left ventricle. Activation of omega receptors has no significant effect on the occurrence of reperfusion arrhythmias ex vivo. Stimulation of cardiac sigma receptors is proposed to prevent myocardial stunning.

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Animals Arrhythmias, Cardiac Blood Pressure Creatine Kinase Electrocardiography Heart Ventricles In Vitro Techniques Myocardial Contraction Myocardial Reperfusion Injury Myocardial Stunning Myocytes, Cardiac Phenazocine Rats Rats, Wistar Receptors, Opioid, delta Ventricular Function English Abstract Journal Article

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L N Maslov, Iu B Lishmanov. [Stimulation of the delta 1-receptors help to decrease reperfusion induced myocardial stunning].. https://pubmed.ncbi.nlm.nih.gov/15131985/

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