A PDZ switch for a cellular stress response.

Christian Schlieker; Axel Mogk; Bernd Bukau

doi:10.1016/s0092-8674(04)00453-2

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A PDZ switch for a cellular stress response.

Christian Schlieker·Axel Mogk·Bernd Bukau

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Abstract

The accumulation of misfolded porins in the periplasm of bacteria triggers a proteolytic cascade, initiated by activation of DegS, a member of the family of HtrA proteases. Activation of DegS ultimately leads to the expression of genes encoding the periplasmic protein folding machinery. A new study now reveals that binding of exposed C-termini of unassembled porins to the PDZ domain of DegS induces structural rearrangements that activate the catalytic site of the protease domain.

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Bacteria Bacterial Proteins Catalytic Domain Porins Protein Binding Protein Folding Comment Journal Article Review

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Christian Schlieker, Axel Mogk, Bernd Bukau. 2004-05-14. A PDZ switch for a cellular stress response.. https://doi.org/10.1016/s0092-8674(04)00453-2

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