Sepsis: avoiding its deadly toll.

Thomas Decker

doi:10.1172/jci21819

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Sepsis: avoiding its deadly toll.

Thomas Decker

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Abstract

Systemic bacterial infection may culminate in a frequently fatal septic shock syndrome. The underlying pathology is the result of an uncontrolled inflammatory response, stimulated by the pathogen and its products. Toll-like receptors (TLRs) are critically involved in sensing bacteria and, in the case of sepsis, stimulate a pathogenic response by the innate immune system. A new study reports a successful attempt to inhibit systemic inflammation in mice by disrupting the formation of complexes between Gram-positive bacteria and their cognate receptor, TLR2.

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Animals Gram-Positive Bacteria Humans Immunity, Innate Inflammation Mediators Membrane Glycoproteins Mice Models, Biological Receptors, Cell Surface Sepsis Shock, Septic Toll-Like Receptor 2 Toll-Like Receptors Comment Journal Article Research Support, Non-U.S. Gov't

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Thomas Decker. 2004. Sepsis: avoiding its deadly toll.. https://doi.org/10.1172/jci21819

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