Checkpoint adaptation; molecular mechanisms uncovered.

Patrick J Lupardus; Karlene A Cimprich

doi:10.1016/j.cell.2004.05.005

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Checkpoint adaptation; molecular mechanisms uncovered.

Patrick J Lupardus·Karlene A Cimprich

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Abstract

Adaptation to the DNA damage checkpoint is a phenomenon long thought to be confined to the unicellular world. A new report in this issue of Cell by suggests the presence of a checkpoint adaptation pathway in Xenopus egg extracts that displays interesting molecular parallels to adaptation in yeast.

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Animals Cell Cycle Cell Cycle Proteins Checkpoint Kinase 2 Genes, cdc Intracellular Signaling Peptides and Proteins Protein Serine-Threonine Kinases Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Xenopus Journal Article Comment

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Patrick J Lupardus, Karlene A Cimprich. 2004-05-28. Checkpoint adaptation; molecular mechanisms uncovered.. https://doi.org/10.1016/j.cell.2004.05.005

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