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Microscopic polyangiitis associated with diffuse panbronchiolitis.

Jangchul Park·Shogo Banno·Yoshiki Sugiura·Kosho Yoshikawa·Taio Naniwa·Kaori Wakita·Yoshihito Hayami·Shigeki Sato·Ryuzo Ueda
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Abstract

There are several case reports of systemic vasculitis associated with chronic suppurative lung diseases. We describe a 46-year-old female, previously diagnosed as having diffuse panbronchiolitis (DPB), presenting with hemosputum and dyspnea. Her serum titer of MPO-ANCA was positive together with a high titer of BPI-ANCA. Chest X-ray and chest CT scan showed pulmonary hemorrhage, and the renal biopsy specimen revealed necrotizing, crescentic glomerulonephritis. She was diagnosed as having ANCA-associated vasculitis, and more specifically, microscopic polyangiitis accompanied by DPB. She was treated with methylprednisolone pulse therapy, followed by intravenous cyclophosphamide. This case suggested a possible association with chronic bacterial infection, which may play a role in the pathogenesis of ANCA-associated vasculitis.

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Antibodies, Antineutrophil CytoplasmicBronchiolitisCholera ToxinFemaleHumansMiddle AgedPeroxidaseRadiographyVasculitisCase ReportsJournal Article

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Jangchul Park, Shogo Banno, Yoshiki Sugiura, Kosho Yoshikawa, Taio Naniwa, Kaori Wakita, Yoshihito Hayami, Shigeki Sato, Ryuzo Ueda. 2004. Microscopic polyangiitis associated with diffuse panbronchiolitis.. https://doi.org/10.2169/internalmedicine.43.331

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