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PubMed · 15187217

Approximate equivalent rosuvastatin doses for temporary statin interchange programs.

Michael G Kendrach·Maisha Kelly-Freeman
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Abstract

OBJECTIVE: To estimate approximate doses of rosuvastatin equivalent to the other hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) for a temporary substitution program. DATA SOURCES: A literature search was conducted to locate clinical trials directly comparing rosuvastatin with other statins that evaluated the magnitude of cholesterol lowering. DATA SYNTHESIS: The mean low-density lipoprotein and total cholesterol values from the clinical trials were assessed. Study results indicate that rosuvastatin is not equivalent to other statins on a milligram-to-milligram basis. CONCLUSIONS: Rosuvastatin appears to be at least 2 and 4 times as potent as atorvastatin and simvastatin, respectively, and at least 8 times as potent as pravastatin and lovastatin.

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CholesterolClinical Trials as TopicDrug InteractionsFluorobenzenesHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHyperlipidemiasLipoproteins, LDLPyrimidinesRosuvastatin CalciumSulfonamidesTherapeutic EquivalencyComparative StudyJournal ArticleReview

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Michael G Kendrach, Maisha Kelly-Freeman. 2004-06-08. Approximate equivalent rosuvastatin doses for temporary statin interchange programs.. https://doi.org/10.1345/aph.1d391

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