Is transplantation tolerable?

Terry B Strom

doi:10.1172/jci22153

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PubMed · 15199402

Is transplantation tolerable?

Terry B Strom

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Abstract

To test the hypothesis that chronic stimulation of T cells with a weak agonistic antigen will generate regulatory T cells and immune tolerance, a study reported in this issue employed the redesign of a minor histocompatibility antigen. Using knowledge of residues at which the antigen contacts the T cell receptor, a weak agonist was produced. Pretreatment with this altered antigen produced transplant tolerance, generation of regulatory T cells, and a loss of many antigen-reactive T cells.

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Animals Female Immune Tolerance Mice Minor Histocompatibility Antigens Organ Transplantation Receptors, Antigen, T-Cell T-Lymphocyte Subsets T-Lymphocytes Comment Journal Article

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Terry B Strom. 2004. Is transplantation tolerable?. https://doi.org/10.1172/jci22153

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