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PubMed · 1521371

Renal vasoconstriction is modulated by nitric oxide.

J J Reid·M J Rand
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Abstract

1. The effect of the nitric oxide synthesis inhibitor, NG-nitro-L-arginine (NOLA), has been examined on vascular reactivity in the rat isolated perfused kidney. 2. NOLA (10 mumol/L) had no effect on basal perfusion pressure, but significantly enhanced the vasoconstrictor responses to sympathetic nerve stimulation (1-16 Hz, 10 s) and noradrenaline (10-300 pmol). The enhancements were greater with the lower frequencies of stimulation and lower doses of noradrenaline. 3. The enhancing effect of 10 mumol/L NOLA on vasoconstrictor responses to nerve stimulation was partially prevented by 100 mumol/L L-arginine while 100 mumol/L D-arginine had no effect. 4. The results suggest that nitric oxide attenuates vasoconstrictor responses in the rat kidney, and provide evidence that nitric oxide has a physiological role in the modulation of vascular reactivity.

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AnimalsArginineElectric StimulationFemaleKidneyMaleNitric OxideNitroarginineNorepinephrinePerfusionRatsRats, Inbred StrainsSympathetic Nervous SystemTime FactorsVasoconstrictionJournal ArticleResearch Support, Non-U.S. Gov't

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J J Reid, M J Rand. 1992. Renal vasoconstriction is modulated by nitric oxide.. https://doi.org/10.1111/j.1440-1681.1992.tb00476.x

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