PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 15221092

[New developments in skin replacement materials].

M Przybilski·R Deb·D Erdmann·G Germann
View original source ↗Export metadata ↓

Abstract

Current treatment strategies in intensive care medicine permit survival of patients with burns of more than 80% of the total body surface area (TBSA). Major burns result in extensive skin defects. Thus, burn victims often suffer from scar contractures, altered thermoregulation, and unsatisfactory cosmetic results. In addition to the well-established cultivated epithelial autografts, a number of new composite grafts have been developed in the field of tissue engineering. The combination of synthetic and allogenic matrix structures together with an allogenic or autologous epithelium allows the possibility of mimicking skin structure. The aim is to achieve improved wound healing by regeneration of dermal tissue instead of scarring. This article provides an overview of the currently available products which have already been introduced into clinical routine as well as describing advantages and disadvantages of the individual products and their indications.

Explore related subjects

Biological DressingsBurnsHumansKeratinocytesSkin TransplantationSkin, ArtificialTissue EngineeringWound HealingComparative StudyEnglish AbstractJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

M Przybilski, R Deb, D Erdmann, G Germann. 2004. [New developments in skin replacement materials].. https://doi.org/10.1007/s00104-004-0860-6

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2005

The cell based dressing with living allogenic keratinocytes in the treatment of foot ulcers: a case study.

In this study, we aimed to investigate the efficacy of cell based dressing with living allogenic keratinocytes in diabetic foot patients. To address this issue, the cultured keratinocytes were attached to the microcarriers produced from polyethylene and silica. The microcarriers were then applied to the wounds at 3-day intervals. Forty patients with grade II and III diabetic foot ulcers were included into the study. The patients were randomised into two groups (n=20). The treatment and control groups received cell based dressing and microcarriers kept in culture medium overnight, respectively. The wound size was recorded at 3 days intervals. The wounds were also categorised by a specific scoring system considering the wound contraction, granulation tissue formation, epithelisation and discharge from the wounds. The high score indicates better condition. The mean reduction of the wound area was 92% in the treatment group and 32% in the control group at the end of the 30 days treatment (p<0.001). When considered the complete healing, the mean number of dressings was 9.2+/-3.2 in the treatment group whereas it was 16.5+/-2.3 in the control group (p<0.001). The initial mean score of the treatment and control groups were 2.5 and 2.35, respectively. At the end of the 30th day, the mean score of the treatment group was 17.15+/-2.7 and of control group was 9.05+/-3. Allogenic keratinocyte treatment delivered with microcarriers can make significant contributions to wound healing in diabetic foot patients.

Biological Dressings↗
PubMed2004

Preparation of semi-interpenetrating polymer networks composed of silk fibroin and poloxamer macromer.

A system was designed to utilize silk fibroin (SF) as a matrix for wound dressing. For this system, we prepared a sponge type of porous semi-interpenetrating networks (SIPNs) hydrogel composed of SF and poloxamer 407 macromer to enhance the mechanical and functional properties of SF. The thermal and mechanical properties of the hydrogels as well as their swelling behaviors were studied by means of differential scanning calorimetry, compressive modulus measurement, and gravimetric method, respectively. The morphology and crystalline structure of these SIPN hydrogels were also investigated by scanning electron microscopy (SEM) and wide-angle diffractometry, respectively. Conformational change of SF from random coil to beta-sheet structure was accelerated by formation of SIPNs with poloxamer. The melting temperature of poloxamer in the SIPNs decreased due to the prevention of crystallization by the incorporation of SF. The mechanical strength of SIPNs hydrogel was much higher than those of SF itself or SF/poloxamer blend and increased with the poloxamer content. The equilibrium water content of SF was remarkably increased by formation of SIPNs with poloxamer due to the hydrophilicity of poloxamer. The crystallinity and morphology of SIPNs hydrogel were affected by SIPNs hydrogel composition.

Biological Dressings↗
PubMed2004

[Amniotic-membrane and limbic stem-cell transplantation in the management of ocular burns].

Severe ocular burns are potentially blinding injuries. During the first month, ocular surface destruction is caused by a vicious circle of complications that may result in the pathological state of total limbal stem-cell deficiency. Amniotic membrane transplantation can be considered an early, if not immediate, surgical procedure to promote epithelialization and calm inflammation so that scarring-induced sequelae can be prevented in the chronic stage. However, when partial or total limbal stem-cell deficiency involves one or both eyes, corneal surface reconstruction relies on transplantation of autologous limbal stem cells, an allogenic source of limbal stem cells or corneal epithelial stem-cell transplantation. In this late stage, amniotic-membrane transplantation may improve prognosis of keratolimbal allograft and is useful in the treatment of symblepharons.

Biological Dressings↗