PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 15264582

[Syncope].

F Mathieu·P Mélon·A Waleffe·L Piérard
View original source ↗Export metadata ↓

Abstract

Syncope remains a clinical challenge. Accurate history taking, physical examination and EKG are mainstays of the diagnosis work up. The most important parameter for prognosis and requiring aggressive management is a structural heart disease. Patient without cardiopathy presenting multiple episodes may be candidate for tilt testing and loop EKG recorder.

Explore related subjects

Diagnosis, DifferentialElectrocardiographyHeart DiseasesHumansMedical History TakingPrognosisSyncopeEnglish AbstractJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

F Mathieu, P Mélon, A Waleffe, L Piérard. 2004. [Syncope].. https://pubmed.ncbi.nlm.nih.gov/15264582/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.

In HLH-94, the first prospective international treatment study for hemophagocytic lymphohistiocytosis (HLH), diagnosis was based on five criteria (fever, splenomegaly, bicytopenia, hypertriglyceridemia and/or hypofibrinogenemia, and hemophagocytosis). In HLH-2004 three additional criteria are introduced; low/absent NK-cell-activity, hyperferritinemia, and high-soluble interleukin-2-receptor levels. Altogether five of these eight criteria must be fulfilled, unless family history or molecular diagnosis is consistent with HLH. HLH-2004 chemo-immunotherapy includes etoposide, dexamethasone, cyclosporine A upfront and, in selected patients, intrathecal therapy with methotrexate and corticosteroids. Subsequent hematopoietic stem cell transplantation (HSCT) is recommended for patients with familial disease or molecular diagnosis, and patients with severe and persistent, or reactivated, disease. In order to hopefully further improve diagnosis, therapy and biological understanding, participation in HLH studies is encouraged.

Diagnosis, Differential↗