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PubMed · 15276117

Endothelial cell function in patients with Down's syndrome.

Maurizio Cappelli-Bigazzi·Giuseppe Santoro·Carmine Battaglia·Maria Teresa Palladino·Marianna Carrozza·Maria Giovanna Russo·Giuseppe Pacileo·Raffaele Calabrò
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Abstract

Patients with Down's syndrome show an increased pulmonary vascular reactivity that could be due to an impaired vascular endothelial function, which is possibly related to increased oxidative stress. In 8 patients with Down's syndrome and 9 euploid patients of similar age, endothelium-dependent and -independent vasodilation was studied, measuring brachial flow velocity with an intravascular Doppler flow wire. Patients with Down's syndrome showed a significant impairment of endothelial function versus controls. In presence of the antioxidant vitamin C, endothelium-dependent vasodilation in the patients with Down's syndrome was only slightly, but not significantly, improved.

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AcetylcholineAnalysis of VarianceAscorbic AcidBlood Flow VelocityBrachial ArteryCase-Control StudiesChildChild, PreschoolDown SyndromeEndothelial CellsEndothelium, VascularFemaleHumansMaleNitroglycerinOxidative StressProbabilityReference ValuesRisk AssessmentUltrasonography, Doppler, PulsedVasodilationJournal Article

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Maurizio Cappelli-Bigazzi, Giuseppe Santoro, Carmine Battaglia, Maria Teresa Palladino, Marianna Carrozza, Maria Giovanna Russo, Giuseppe Pacileo, Raffaele Calabrò. 2004-08-01. Endothelial cell function in patients with Down's syndrome.. https://doi.org/10.1016/j.amjcard.2004.04.047

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