High-throughput characterization and quality control of small-molecule combinatorial libraries.

Jeremy R Kenseth; Shelley J Coldiron

doi:10.1016/j.cbpa.2004.06.004

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High-throughput characterization and quality control of small-molecule combinatorial libraries.

Jeremy R Kenseth·Shelley J Coldiron

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Abstract

To fully realize the potential of combinatorial synthesis and high-throughput screening for increasing the efficiency of the drug discovery and development process, issues related to compound purity must be addressed. Impurities, often present after synthesis, can lead to ambiguous screening results and inhibit the development of quality structure-activity relationships. The demand for high-throughput analytical characterization of combinatorial libraries has prompted the development of more rapid methods to keep pace with compound production. Recent progress has focused upon the development of parallel separation methods, multiplexed detector interfaces, and synergistic combinations of different detectors possessing complementary selectivities.

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Combinatorial Chemistry Techniques Drug Design Drug Evaluation, Preclinical Magnetic Resonance Spectroscopy Mass Spectrometry Molecular Weight Quality Control Structure-Activity Relationship Time Factors Journal Article Review

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Jeremy R Kenseth, Shelley J Coldiron. 2004. High-throughput characterization and quality control of small-molecule combinatorial libraries.. https://doi.org/10.1016/j.cbpa.2004.06.004

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