Ligand binding with continuous modification of binding sites.

V B Arakelyan; S G Haroutiunian; H H Abgaryan; A V Arakelyan; T S Haroutunyan

doi:10.1080/07391102.2004.10506999

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Ligand binding with continuous modification of binding sites.

V B Arakelyan·S G Haroutiunian·H H Abgaryan·A V Arakelyan·T S Haroutunyan

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Abstract

Simultaneous formulation binding and structure modification of the binding site leads to binding process that can be analyzed within the framework of the non-linear theory of dynamic systems. Such an approach allows us to obtain several properties of the binding center: plurality of stationary (stable and unstable) states at binding, recognition of bistable and hysteretic binding modes. It is also shown that adsorption centre deformation leads to a S-shaped adsorption curve.

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Adsorption Binding Sites Ligands Macromolecular Substances Molecular Conformation Thermodynamics Journal Article Research Support, Non-U.S. Gov't

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V B Arakelyan, S G Haroutiunian, H H Abgaryan, A V Arakelyan, T S Haroutunyan. 2004. Ligand binding with continuous modification of binding sites.. https://doi.org/10.1080/07391102.2004.10506999

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