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Functional magnetic ventilation in dogs.

Vernon W Lin·Ian Hsiao·Xiaoming Deng·Yu-Sheng Lee·Scott Sasse
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Abstract

OBJECTIVE: To investigate the efficacy of the magnetic stimulation of inspiratory muscles as an alternative to mechanical ventilation and functional electric stimulation. DESIGN: A prospective before-after trial. SETTING: Functional magnetic stimulation laboratory in a Veterans Administration health care system. ANIMALS: Six male mongrel dogs, each weighing between 25 and 35 kg. INTERVENTIONS: Commercially available magnetic stimulators with a round magnetic coil were used. The center of the magnetic coil was placed posteriorly over the C5-7 vertebrae of the spinal cord transected dogs. Magnetic stimulation parameters were set at 80% intensity, 20 Hz, and a 1.2-second on and 3.8-second off pulse train. MAIN OUTCOME MEASURES: The major outcomes were changes in tidal volume (VT), tracheal pressure (Ptr), and arterial partial pressure of carbon dioxide (PaCO2) and oxygen sustained by magnetic stimulation over time. RESULTS: The average Vt and Ptr produced during functional magnetic ventilation (FMV) were.47+/-.07 L and -4.7+/-.51 cmH2O, respectively. Blood gas data showed that PaCO2 increased from a baseline of 33 to 75 mmHg, whereas pH decreased from 7.33 to 6.99 at the end of the 1-hour FMV period. CONCLUSIONS: FMV was achieved for 2 hours in dogs with C2 spinal cord transection. Additional refinements in magnetic stimulation are needed to improve ventilation in animals.

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Analysis of VarianceAnimalsBlood Gas AnalysisCarbon DioxideCervical VertebraeDisease Models, AnimalDogsHydrogen-Ion ConcentrationLactic AcidMagneticsMaleMuscle FatigueOxygenOxygen ConsumptionPhrenic NerveProspective StudiesRespiration, ArtificialRespiratory InsufficiencyRespiratory MusclesSpinal Cord InjuriesTidal VolumeTime FactorsTreatment OutcomeVentilators, Negative-PressureJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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Vernon W Lin, Ian Hsiao, Xiaoming Deng, Yu-Sheng Lee, Scott Sasse. 2004. Functional magnetic ventilation in dogs.. https://doi.org/10.1016/j.apmr.2003.10.025

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