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PubMed · 15388103

Alternative quality control for technetium-99m IDA complexes.

Mervyn W Billinghurst·Kellie Eckert·Kennedy Mang'era
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Abstract

A quality control procedure for 99mTc-IDA complexes based on the use of C18 Sep-pak cartridges is developed and the validation of the procedure presented. C18 Sep-pak cartridges are pretreated by washing with 95% ethanol followed by 10(-3) N hydrochloric acid. A small amount of the 99mTc-IDA complex is applied, washed with 10(-3) N hydrochloric acid and eluted with 95% ethanol. The radiochemical purity values obtained for 99mTc-mebrofenin and 99mTc-disofenin using this Sep-pak procedure are comparable to those obtained using the standard two strip (ITLC-SG/100% methanol, ITLC-SA/20% saline) procedure.

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Chromatography, Thin LayerImino AcidsOrganotechnetium CompoundsQuality Assurance, Health CareRadiopharmaceuticalsSilicon DioxideComparative StudyEvaluation StudyJournal ArticleValidation Study

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Mervyn W Billinghurst, Kellie Eckert, Kennedy Mang'era. 2004. Alternative quality control for technetium-99m IDA complexes.. https://doi.org/10.1016/j.apradiso.2004.03.101

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