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227Th-EDTMP: a potential therapeutic agent for bone metastasis.

Kohshin Washiyama·Ryohei Amano·Jun Sasaki·Seigo Kinuya·Norihisa Tonami·Yoshinobu Shiokawa·Toshiaki Mitsugashira
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Abstract

The biodistribution of 227Th-EDTMP and retention of its daughter nuclide 223Ra were examined. 227Th-EDTMP was found to show high uptake and long-term retention in bone. The clearance of 227Th-EDTMP from blood and soft tissues was rapid and the femur-to-tissue uptake ratios reached more than 100 within 30 min for all tissues except the kidney. Seven and 14 days after injection of 227Th-EDTMP, the retention index of 223Ra in bone showed high values, and the differences between these time points were not significant. Therefore, 227Th-EDTMP is a potential radiotherapeutic agent for bone metastasis.

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AnimalsBone NeoplasmsFeasibility StudiesFemurMaleMetabolic Clearance RateMiceMice, Inbred ICROrgan SpecificityOrganometallic CompoundsOrganophosphonatesRadiopharmaceuticalsTissue DistributionEvaluation StudyJournal ArticleResearch Support, Non-U.S. Gov't

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Kohshin Washiyama, Ryohei Amano, Jun Sasaki, Seigo Kinuya, Norihisa Tonami, Yoshinobu Shiokawa, Toshiaki Mitsugashira. 2004. 227Th-EDTMP: a potential therapeutic agent for bone metastasis.. https://doi.org/10.1016/j.nucmedbio.2004.05.001

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