PubMed · 15467687
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Mildred S Dresselhaus. 2004. A step in synthesis.. https://doi.org/10.1038/nmat1232
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Single-walled carbon nanotubes (SWCNTs) show promise for probing molecular interactions at single-molecule resolution, yet generating SWCNT populations bearing a single defined functional tag remains challenging because surface functionalization is inherently stochastic. Here, we present a batch-scale strategy to produce predominantly singly tagged SWCNTs by leveraging the stochastic adsorption of single-stranded DNA (ssDNA). Specifically, SWCNTs are dispersed using a mixture of unmodified ssDNA (um-ssDNA) and a minor fraction of modified ssDNA (m-ssDNA) carrying an affinity handle. We developed a probabilistic ssDNA-SWCNT binding model that predicts the distribution of m-ssDNA per nanotube as a function of the input minor-strand fraction p = m-ssDNA/total ssDNA, enabling selection of conditions that maximize single-tag purity. Using magnetic-bead capture via a biotin affinity interaction and subsequent release, we isolate SWCNTs with 97.6% predicted single-tag purity at 2% recovery. Single-molecule fluorescence imaging further supports predominantly single-label occupancy under the model-selected conditions. Thus, this approach provides a general route to SWCNTs bearing a single molecular handle for downstream conjugation and assembly, supporting diverse future applications in SWCNT-based nanotechnologies.
By using controlled SPM manipulation, carbon nanotubes have been continuously bent into a series of increasing angles, and two distinct buckling modes corresponding to "abrupt" and "gradual" buckle formation were observed through recording the height increment at the bend site during the loading process. Molecular dynamics simulation also found the two buckling modes in different types of carbon nanotubes, and their atomistic mechanism was revealed. Finally, the dependence of the critical buckling condition on diameters of carbon nanotubes was tentatively studied.
Single bilayer membranes of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) were formed on micron thin-films of hydrophilized carbon nanotubes (CNT) by fusion of small unilamellar vesicles. The structure of the membrane was investigated using neutron reflectivity (NR). The underlying thin film of CNT was formed by chemical vapor deposition (CVD) in the presence of Fe catalyst, followed by reaction with 5 M nitric acid to render the film hydrophilic. We demonstrate that this platform lends support to homogeneous and continuous bilayer membranes that have promising applications in the fields of biomaterials, biosensors, and biophysics.