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Antigen-driven T cell expansion: affinity rules.

Jonathan D Ashwell
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Abstract

TCR affinity and ligand off-rate have both been found to influence the degree of T cell activation by peptide-MHC. A report in this issue of Immunity finds that ligand off-rate does not correlate with antigen-specific peripheral T cell expansion. Moreover, the data point to the surprising notion that there exist TCR affinity thresholds and, once attained, T cells with higher affinity receptors have no competitive advantage.

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AnimalsCytochromes cHistocompatibility Antigens Class IIMiceReceptors, Antigen, T-CellT-Lymphocytes, Helper-InducerCommentJournal Article

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Jonathan D Ashwell. 2004. Antigen-driven T cell expansion: affinity rules.. https://doi.org/10.1016/j.immuni.2004.11.001

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