What determines glomerular capillary permeability?

William M Deen

doi:10.1172/jci23577

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What determines glomerular capillary permeability?

William M Deen

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Abstract

There have been exciting recent advances in our understanding of the structural and molecular biology of the glomerular slit diaphragm, as described in a report in this issue of the JCI. These findings, combined with data on the permeability of the basement membrane and evidence that the endothelium may be a more important barrier than often supposed, are allowing a clearer understanding to emerge of how the 3 parts of the glomerular capillary wall jointly determine its functional properties.

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Animals Basement Membrane Capillaries Capillary Permeability Endothelium, Vascular Epithelial Cells Humans Kidney Glomerulus Membrane Proteins Mice Mice, Knockout Models, Biological Proteins Comment Journal Article

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William M Deen. 2004. What determines glomerular capillary permeability?. https://doi.org/10.1172/jci23577

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