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Intercellular adhesion molecule-1 expression in nasal polyps treated with corticosteroid.

Fehmi Doner·Ibrahim Sari·Murat Yariktas·Harun Dogru
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Abstract

PURPOSE: The aim of this study was to compare intracellular adhesion molecule-1 (ICAM-1) expression in nasal polyp cases who were administered topical corticosteroid and in middle turbinates. MATERIALS AND METHODS: Twenty-four patients with nasal polyps were included in the study group. These patients were treated with 100 microg budesonide in each nostril twice daily for 2 months before the surgery. Twenty-one nonatopic patients with concha bullosa were included in the control group. The specimens were taken from patients undergoing endoscopic surgery. RESULTS: In polyps, significantly higher mean ICAM-1 intensity scores were found by comparison with the control turbinates. CONCLUSIONS: Corticosteroid treatment in patients with nasal polyps does not diminish ICAM-1 to that of turbinate tissue. The initiating events in the formation of nasal polyps still occur in these patients despite treatment with the topical nasal steroid.

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Administration, IntranasalAdultAnti-Inflammatory AgentsBudesonideCase-Control StudiesEndotheliumFemaleHumansIntercellular Adhesion Molecule-1MaleNasal PolypsTurbinatesJournal Article

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Fehmi Doner, Ibrahim Sari, Murat Yariktas, Harun Dogru. Intercellular adhesion molecule-1 expression in nasal polyps treated with corticosteroid.. https://doi.org/10.1016/j.amjoto.2004.04.014

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