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Spasmolytic stilbenoids from Maxillaria densa.

S Estrada·J J López-Guerrero·R Villalobos-Molina·R Mata
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Abstract

2,5-dihydroxy-3,4-dimethoxyphenanthrene (1), fimbriol-A (2), nudol (3), gymnopusin (4) and erianthridin (5) isolated from Maxillaria densa provoked a concentration-dependent inhibition of the spontaneous contractions of the rat ileum with potencies comparable to papaverine. In order to establish the mode of action of stilbenoids 1-5, their effect on the contractions induced by different spasmogens (histamine, barium chloride and L-NAME) was investigated. In general, the results suggested that the relaxant activity of the products does not involve a direct nitrergic or antihistaminergic mode of action or an interference with calcium influx into the smooth muscle cells.

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AnimalsDose-Response Relationship, DrugIleumMaleMuscle ContractionOrchidaceaeParasympatholyticsPhytotherapyPlant ExtractsRatsRats, WistarStilbenesJournal ArticleResearch Support, Non-U.S. Gov't

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S Estrada, J J López-Guerrero, R Villalobos-Molina, R Mata. 2004. Spasmolytic stilbenoids from Maxillaria densa.. https://doi.org/10.1016/j.fitote.2004.08.004

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