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PubMed · 155804

Thymic deficiency in Down's syndrome.

S Levin·M Schlesinger·Z Handzel·T Hahn·Y Altman·B Czernobilsky·J Boss
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Abstract

Children with Down's syndrome (DS) often have small and abnormal thymuses, with lymphocyte depletion, diminution of the cortex, and loss of corticomedullary demarcation--a picture resembling thymic involution. Besides this, they have markedly enlarged Hassall's corpuscles, some surrounded by a sheath of lymphocytes. Patients with DS are known to have increased numbers of respiratory infections; they also have a higher incidence of lymphatic leukemia than do individuals who do not have DS. Studies of cell-mediated (thymic-dependent) immunity demonstrate that children with DS have both diminished numbers of T cells as well as functional deficiency of these cells.

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ChildChild, PreschoolDown SyndromeFemaleHumansImmunity, CellularInfantInfant, NewbornInterferonsLymphokinesMaleThymus GlandComparative StudyJournal Article

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S Levin, M Schlesinger, Z Handzel, T Hahn, Y Altman, B Czernobilsky, J Boss. 1979. Thymic deficiency in Down's syndrome.. https://pubmed.ncbi.nlm.nih.gov/155804/

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