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PubMed · 15587116

Phostoxin-induced biochemical and pathomorphological changes in rabbits.

Ngozi Paulinus Okolie·Jonathan Umezuluike Aligbe·Edorisiagbon Eguagu Osakue
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Abstract

The effect of chronic phostoxin administration on some tissue ATPases, hematology and tissue histopathology was investigated using a combination of gravimetric, enzymatic, colorimetric and histological procedures in New Zealand White rabbits after 2 weeks administration of 0.8mg phostoxin/kg body weight/day, po. The phostoxin treatment led to significant decreases in Na(+)-K+ ATPase activities in renal, hepatic and cardiac tissues. Similar decreases were obtained in the activities of Ca(2+)-ATPase and Mg(2+)-ATPase in liver. In addition, the phostoxin-toxified rabbits manifested significant decreases in hematocrit, red blood cell count, hemoglobin and platelets. Histological examination of the tissues revealed pronounced degenerative changes in liver, heart and kidney.

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Aluminum CompoundsAnimalsCa(2+) Mg(2+)-ATPaseCalcium-Transporting ATPasesErythrocyte CountHeartKidneyLiverPesticidesPhosphinesRabbitsSodium-Potassium-Exchanging ATPaseWater Pollutants, ChemicalJournal Article

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Ngozi Paulinus Okolie, Jonathan Umezuluike Aligbe, Edorisiagbon Eguagu Osakue. 2004. Phostoxin-induced biochemical and pathomorphological changes in rabbits.. https://pubmed.ncbi.nlm.nih.gov/15587116/

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