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PubMed · 15600202

[Experimental study on estrogenic function of triphasic contraceptive tablets].

Fangju Yang·Min Zhang·Ling Zhu·Guanqiang Zhou·Suznen Zhou·Ailan Fan
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Abstract

OBJECTIVE: To assess the estrogenic effect and activity of oral triphasic contraceptive tablets and provide the theoretical foundation for the use of homemade Kalirui in the treatment of metrorrhagic, menometrorrhagic, oligomenorrheic, and polymenorrheic dysfunctional uterine bleeding. METHODS: The vaginal smears of mice treated by triphasic contraceptive tablets (Kalirui and Trinordiol) were examined using light microscope. Radiational receptor analysis was made to measure the estrogenic effect of Kalirui and Trinordiol on Compared with the control group, the three dosage groups of homemade (Kalirui) rabbit uterus. RESULTS: triphasic contraceptive tablets and the import tablets (Trinordiol) group all showed obviously accelerate vagina kera-epithelium forming (P < 0.01), especially in the first phase and second phase. Both Kalirui and Trinordiol were found to have higher affinity to estrogenic receptor, and there were no significant differences between them Kalirui and Trinordiol triphasic oral contraceptive and the estrogenic standard sample (P > 0.05). CONCLUSION: tablets have apparently estrogenic effect and activity.

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AnimalsContraceptives, Oral, SyntheticEpithelial CellsEstrogens, Non-SteroidalEthinyl Estradiol-Norgestrel CombinationFemaleLevonorgestrelMiceRandom AllocationReceptors, EstrogenVaginaEnglish AbstractJournal Article

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Fangju Yang, Min Zhang, Ling Zhu, Guanqiang Zhou, Suznen Zhou, Ailan Fan. 2003. [Experimental study on estrogenic function of triphasic contraceptive tablets].. https://pubmed.ncbi.nlm.nih.gov/15600202/

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