Active control and its stress effects.

M V Kondashevskaya; K A Nikol'skaya

doi:10.1023/b:bebm.0000048391.44182.a7

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Active control and its stress effects.

M V Kondashevskaya·K A Nikol'skaya

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Abstract

The effects of 5-fold injections of normal saline were studied in Wistar rats in two conditioned reflex situations: defense and alimentary. Intact animals developed conditioned pain avoidance reflex in repeated tail-flick test after 60 presentations over 3 days. Two injections of normal saline were sufficient for the formation of a stable negative stress status in experimental rats, which manifested by a drastic increase in tactile sensitivity persisting for 5 days after discontinuation of injections. Only 15% experimental rats vs. 40% intact animals developed the food-procuring response in a multialternative maze. Presumably, repeated injections of normal saline should be regarded as a potent negative stress factor modulating animals behavior, and these signs should be taken into consideration, when interpreting the effects observed in pharmacological investigations.

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Animals Avoidance Learning Conditioning, Classical Injections, Intraperitoneal Male Maze Learning Rats Rats, Wistar Sodium Chloride Stress, Physiological Journal Article

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M V Kondashevskaya, K A Nikol'skaya. 2004. Active control and its stress effects.. https://doi.org/10.1023/b%3Abebm.0000048391.44182.a7

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