Ability of L-histidine to decrease desensitization of the myometrium to epinephrine.

T V Tumanova; E N Sizova; V I Tsirkin

doi:10.1007/s10517-005-0031-x

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Ability of L-histidine to decrease desensitization of the myometrium to epinephrine.

T V Tumanova·E N Sizova·V I Tsirkin

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Abstract

Experiments were performed with 62 longitudinal strips of the uterine horns from 10 nonpregnant rats. The ability of continuously infused epinephrine in high concentration (10(-6) g/ml, 30 min) to suppress spontaneous contractions due to activation of beta-adrenoceptors progressively decreased, which was associated with receptor desensitization. Histidine in a concentration of 3 x 10(-11) g/ml had no effect, while in concentrations of 3 x 10(-8), 3 x 10(-7), and 3 x 10(-6) g/ml decreased the degree of desensitization. Our results indicate that histidine not only potentiates beta-adrenoceptor activation, but also prevents the development of desensitization. These data should be taken into account during therapy with beta-adrenoceptor agonists.

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Animals Drug Interactions Drug Resistance Epinephrine Female Histidine In Vitro Techniques Myometrium Rats Receptors, Adrenergic, beta Uterine Contraction Journal Article

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T V Tumanova, E N Sizova, V I Tsirkin. 2004. Ability of L-histidine to decrease desensitization of the myometrium to epinephrine.. https://doi.org/10.1007/s10517-005-0031-x

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