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Reactions of cellulose isothiocyanates with thiol and amino compounds.

P Gemeiner·J Augustín·L Drobnica
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Abstract

A cellulose isothiocyanate has been prepared by treatment of cellulose with 2,4-di-isocyanatotoluene followed by hydrolysis and reaction of the resulting amine with thiophosgene. The cellulose isothiocyanate was characterized by its binding capacity with respect to [14C]-glycine, [131 I]-human serum albumin, and 2-mercaptoethanol. An analytical method for binding capacity, based on reaction with [35 S]-alpha-toluenethiol, was developed. Because of the aromatic character of the NCS group of the cellulose isothiocyanate, the covalently bonded thiol can be quantitatively liberated.

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Binding SitesCelluloseGlycineHumansHydrogen-Ion ConcentrationKineticsMercaptoethanolProtein BindingSerum AlbuminThiocyanatesJournal Article

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P Gemeiner, J Augustín, L Drobnica. 1977. Reactions of cellulose isothiocyanates with thiol and amino compounds.. https://doi.org/10.1016/s0008-6215(00)88089-1

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