[Visual functions in optic neuritis].

N Jirásková; P Rozsíval

Home/Archive/PubMed

PubMed · 15745407

[Visual functions in optic neuritis].

N Jirásková·P Rozsíval

View original source ↗Export metadata ↓

Abstract

The authors present results of retrospective study of 25 patients with the first attack of acute optic neuritis followed at the Department of Ophthalmology, University Hospital Hradec Králové. Visual functions were deteriorated in all patients. Visual acuity was in range between 0.8 to hand movement. Central scotoma was present in 12 patients, other visual field patterns were seen in 13 patients. Complete recovery of visual functions was observed in 24 patients during the six months. Patients were examined for signs of multiple sclerosis (MS). In the group without MS (15 patients) were three treated with steroids (2 received intravenous methylprednisolone and 1 oral prednisone before referral to us), vitamins were administered to the others. The patients with proved MS were managed at the Department of Neurology, University Hospital, Hradec Králové.

Explore related subjects

Acute Disease Adult Female Humans Male Middle Aged Optic Neuritis Visual Acuity Visual Fields English Abstract Journal Article Research Support, Non-U.S. Gov't

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

N Jirásková, P Rozsíval. 2004. [Visual functions in optic neuritis].. https://pubmed.ncbi.nlm.nih.gov/15745407/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2008

The effect of acute pain crisis on exhaled nitric oxide levels in children with sickle cell disease.

Exhaled nitric oxide (FE(NO)) has been shown to be decreased in children with sickle cell disease. We sought to evaluate the effect of sickle cell vaso-occlusive crisis (VOC) on FE(NO) levels. We measured FE(NO) levels in 42 children with sickle cell disease, 29 in their baseline health and 13 during an acute VOC. There was no difference in FE(NO) levels between children at baseline (15.12 +/- 9.32 ppb) and those during an acute VOC (15.68 +/- 7.26 ppb; P = 0.794). FE(NO) is not a useful marker of acute VOC in children with sickle cell disease.

Acute Disease↗

PubMed2007

Chemotherapy for myeloid malignancy in children with Fanconi anemia.

BACKGROUND: Children with Fanconi anemia (FA) have a markedly increased risk of developing myeloid malignancies. Historically, patients with FA and myeloid malignancy have extremely poor outcomes. There are currently no clinical trials or case series addressing the use of chemotherapy for children with FA, except in the context of preparative regimens for stem cell transplantation (SCT). In this report we describe the toxicity of a chemotherapy approach for patients with FA and myeloid malignancy to achieve cytoreduction prior to SCT. PATIENTS AND METHODS: Four patients with FA and myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) were treated with chemotherapy (fludarabine 30 mg/m(2) and cytosine arabinoside 300 mg/m(2) each on days 2-4 and granulocyte-colony stimulating factor (G-CSF) 5 microg/kg on days 1-5), termed reduced intensity FLAG prior to SCT. RESULTS: The chemotherapy was well tolerated with expected hematologic toxicity and no measurable toxicity in other organs. Two of the three patients with AML cleared blasts from their bone marrow. Reduction in marrow cellularity was also achieved in one patient with hypercellular MDS. CONCLUSION: These data indicate that children with FA and myeloid malignancy can tolerate chemotherapy and achieve clearance of disease. It remains unclear whether pre-SCT chemotherapy improves currently poor survival rates for SCT in FA patients with myeloid malignancies and further studies are needed to determine if there is a clinical role for this strategy.

Acute Disease↗

PubMed2007

Misspecified regression model for the subdistribution hazard of a competing risk.

We consider a competing risks setting, when evaluating the prognostic influence of an exposure on a specific cause of failure. Two main regression models are used in such analyses, the Cox cause-specific proportional hazards model and the subdistribution proportional hazards model. They are exemplified in a real data example focusing on relapse-free interval in acute leukaemia patients. We examine the properties of the estimator based on the latter model when the true model is the former. An explicit relationship between subdistribution hazards ratio and cause-specific hazards ratio is derived, assuming a flexible parametric distribution for latent failure times.

Acute Disease↗