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Harmonic phase-dispersion microscope with a Mach-Zehnder interferometer.

Andrew Ahn·Changhuei Yang·Adam Wax·Gabriel Popescu·Christopher Fang-Yen·Kamran Badizadegan·Ramachandra R Dasari·Michael S Feld
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Abstract

Harmonic phase-dispersion microscopy (PDM) is a new imaging technique in which contrast is provided by differences in refractive index at two harmonically related wavelengths. We report a new configuration of the harmonic phase-dispersion microscope in a Mach-Zehnder geometry as an instrument for imaging biological samples. Several improvements on the earlier design are demonstrated, including a single-pass configuration and acousto-optic modulators for generating the heterodyne signals without mechanical arm scanning. We demonstrate quantitative phase-dispersion images of test structures and biological samples.

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Equipment DesignEquipment Failure AnalysisMicroscopy, InterferenceMicroscopy, Phase-ContrastOnionsPhantoms, ImagingEvaluation StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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Andrew Ahn, Changhuei Yang, Adam Wax, Gabriel Popescu, Christopher Fang-Yen, Kamran Badizadegan, Ramachandra R Dasari, Michael S Feld. 2005-03-01. Harmonic phase-dispersion microscope with a Mach-Zehnder interferometer.. https://doi.org/10.1364/ao.44.001188

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