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Reduced replication: a call to ARMS.

Michael A Resnick
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Abstract

In this issue of Cell, Lemoine et al. monitor chromosome instability in yeast cells with reduced levels of an essential replicative DNA polymerase. The authors identify a hotspot for chromosome aberrations reminiscent of fragile sites in human cells. This hotspot is composed of inverted Ty elements, which lead to a double-strand break under conditions of limited replication.

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AnimalsChromosomal InstabilityChromosome AberrationsDNADNA RepairDNA ReplicationDNA-Directed DNA PolymeraseHumansRetroelementsYeastsCommentJournal ArticleReview

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Michael A Resnick. 2005-03-11. Reduced replication: a call to ARMS.. https://doi.org/10.1016/j.cell.2005.02.028

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