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Biosensors based on binding-modulated donor-acceptor distances.

Chunhai Fan·Kevin W Plaxco·Alan J Heeger
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Abstract

The promising recognition characteristics exhibited by biomolecules have caused significant interest in biomolecule-based sensor strategies. Here we review several emerging biosensor designs that use modulated electron or energy transfer to a bio-specific ligand as the signaling mechanism. The efficiencies of both electron transfer and energy transfer are strongly dependent on donor-acceptor distance. When coupled with the large conformational changes sometimes associated with biomolecular recognition, these distance-dependent processes provide a robust means for generating optical and electronic signals.

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Biosensing TechniquesFluorescence Resonance Energy TransferQuantum DotsJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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BibTeXRIS

Chunhai Fan, Kevin W Plaxco, Alan J Heeger. 2005. Biosensors based on binding-modulated donor-acceptor distances.. https://doi.org/10.1016/j.tibtech.2005.02.005

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