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Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances.

Larry A Bauer·Douglas J Black·Jennifer S Lill·Julie Garrison·Vidmantas A Raisys·Thomas M Hooton
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Abstract

Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.

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AcecainideAdultAnti-Arrhythmia AgentsAnti-Bacterial AgentsCiprofloxacinCross-Over StudiesDrug InteractionsFemaleHumansKidneyLevofloxacinMaleOfloxacinProcainamideClinical TrialJournal ArticleRandomized Controlled Trial

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Larry A Bauer, Douglas J Black, Jennifer S Lill, Julie Garrison, Vidmantas A Raisys, Thomas M Hooton. 2005. Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances.. https://doi.org/10.1128/aac.49.4.1649-1651.2005

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