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Protocol for mitomycin C use in glaucoma surgery.

J A Maquet·E Dios·J Aragón·C Bailez·F Ussa·N Laguna
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Abstract

PURPOSE: To evaluate the results of a protocol described for mitomycin C (MMC) use in trabeculectomy or combined surgery (phacoemulsification and trabeculectomy). METHODS: A total of 143 eyes (60 trabeculectomies and 83 combined surgeries) of 124 patients were divided into four groups: group 1 (without MMC); group 2 (with 0.1 mg/ml MMC); group 3 (with 0.2 mg/ml MMC), and group 4 (with 0.4 mg/ml MMC). Two-minute MMC was used in every case in groups 2, 3 and 4. The results were analysed after 1 year of follow-up. Intraocular pressure (IOP) and complications were evaluated. Successful IOP control was defined when IOP was <21 mmHg and <16 mmHg if advanced glaucoma was present, always without additional medical treatment. RESULTS: Mean preoperative IOP decreased from 24.60 mmHg (SD 1.40 mmHg) to 13.47 mmHg (SD 0.37 mmHg) (p < 0.00001), 12 months postoperatively. Control in IOP was achieved in 79.02% of eyes. No significant differences were found in final mean IOP values (p > 0.196) or in postoperative complications (p > 0.120) in groups 2, 3 and 4. CONCLUSION: With the protocol described, a selection of concentration of MMC has been made in different clinical forms of glaucoma. No significant differences in IOP control and postoperative complications were noticed among the groups.

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AgedAntibiotics, AntineoplasticClinical ProtocolsConjunctivaFemaleGlaucomaHumansIntraocular PressureMaleMitomycinPhacoemulsificationPractice Guidelines as TopicProspective StudiesScleraSurgical FlapsTime FactorsTrabeculectomyJournal Article

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J A Maquet, E Dios, J Aragón, C Bailez, F Ussa, N Laguna. 2005. Protocol for mitomycin C use in glaucoma surgery.. https://doi.org/10.1111/j.1600-0420.2005.00437.x

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