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Current thinking on the relationship between rhinosinusitis and asthma.

Alpa Laheri Jani·Daniel L Hamilos
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Abstract

An observation made initially on clinical grounds and epidemiologic evidence, i.e., that rhinosinusitis and asthma are closely linked diseases is now supported by a growing body of scientific evidence. Most recent evidence supports the characterization of rhinosinusitis and asthma as two compartmental expressions of a common mucosal susceptibility to exogenous stimuli. In addition, there is evidence that the compartmental processes can affect and amplify each other via a systemic intermediary. The bone marrow is involved in this process, and IL-5 may be a key cytokine for orchestrating the systemic interaction. These facts argue that rhinosinusitis and asthma are not simply localized disease processes but part of a systemic inflammatory disease affecting the respiratory tract. They also provide a compelling rationale for combined treatment strategies with consideration of the treatment of rhinosinusitis as a means of improving asthma control and monitoring for signs of bronchial involvement in those with rhinosinusitis.

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AsthmaClinical Trials as TopicComorbidityHumansInflammationRespiratory SystemRhinitisRisk FactorsSinusitisJournal ArticleReview

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Alpa Laheri Jani, Daniel L Hamilos. 2005. Current thinking on the relationship between rhinosinusitis and asthma.. https://doi.org/10.1081/jas-200044744

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