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Malaria virulence genes controlling expression through chromatin modification.

Kirk W Deitsch
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Abstract

Mutually exclusive expression within the var gene family of the malaria parasite Plasmodium falciparum is important for parasite survival and virulence. In this issue of Cell, Duraisingh et al. and Freitas-Junior et al. provide evidence for the role of Sir2-dependent alterations in chromatin structure and changes in subnuclear chromatin localization in regulating var gene expression (Duraisingh et al., 2005; Freitas-Junior et al., 2005).

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AnimalsAntigenic VariationCell CompartmentationCell NucleusChromatin Assembly and DisassemblyGene Expression RegulationGene SilencingGenes, ProtozoanHeterochromatinMalaria, FalciparumPlasmidsPlasmodium falciparumTelomereVirulenceCommentJournal Article

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Kirk W Deitsch. 2005-04-08. Malaria virulence genes controlling expression through chromatin modification.. https://doi.org/10.1016/j.cell.2005.03.019

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