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Testing various herbs for antithrombotic effect.

Junichiro Yamamoto·Kaori Yamada·Aki Naemura·Tsutomu Yamashita·Ryo Arai
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Abstract

OBJECTIVE: Prevention of arterial thrombotic diseases has high priority in developed countries. Because people who eat inappropriate food are prone to thrombotic events, regular intake of an antithrombotic diet may offer a convenient and effective way of prevention. The aim of the present study was to find herbs that have antithrombotic effects. METHODS: Herbs were crushed and centrifuged and the juice obtained was filtered. The effect of filtrate on platelet-rich thrombus formation was assessed by a shear-induced in vitro platelet function test (hemostatometry). Filtrates showing significant antithrombotic activity were further assessed by using a laser-induced in vivo thrombosis test in mice. The effect of orally administered herb filtrates on flow-mediated vasodilation was also measured. RESULTS: Common thyme and rosemary showed significant antithrombotic activity in vitro and in vivo. Neither herb affected flow-mediated vasodilation. CONCLUSION: Some herbs possess antithrombotic effects in experimental models of thrombosis. The mechanism of the antithrombotic effect of common thyme and rosemary may involve a direct inhibitory effect on platelets.

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AnimalsBlood CoagulationFibrinolytic AgentsMaleMiceMice, Inbred C57BLPhytotherapyPlant ExtractsPlants, MedicinalPlatelet AggregationPlatelet Function TestsRatsRats, WistarRosmarinusThrombosisThymus PlantVasodilationJournal Article

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Junichiro Yamamoto, Kaori Yamada, Aki Naemura, Tsutomu Yamashita, Ryo Arai. 2005. Testing various herbs for antithrombotic effect.. https://doi.org/10.1016/j.nut.2004.09.016

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