PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 15851956

[Keratoconus: current surgical options].

J Colin·S Simonpoli
View original source ↗Export metadata ↓

Abstract

The treatment of keratoconus is in part dependant on the severity of the disease process. When contact lenses fail because of patient intolerance or insufficient acuity to meet the patient's needs, penetrating keratoplasty is the usual surgical modality considered for satisfactory visual rehabilitation. Keratoconus is considered to be a contraindication for incisional refractive surgery such as radial keratotomies or LASIK because of the corneal instability conferred by these procedures. When the cornea is transparent, INTACS implantation is a refractive modality that may improve visual function and in some instances prevent the need for corneal transplantation in select patients with keratoconus.

Explore related subjects

Corneal TransplantationHumansKeratoconusOphthalmologic Surgical ProceduresEnglish AbstractJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J Colin, S Simonpoli. 2005. [Keratoconus: current surgical options].. https://doi.org/10.1016/s0181-5512(05)81045-9

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

How effective is penetrating corneal transplantation? Factors influencing long-term outcome in multivariate analysis.

BACKGROUND: In a large patient cohort, we investigated long-term corneal graft outcome, risk factors for graft failure, and whether corneal graft survival had improved over time. METHODS: Records of 10,952 full-thickness corneal grafts with associated archival follow-up were examined within a prospectively-maintained, national database of 13,831 records, with follow-up extending for up to 18 years. Kaplan-Meier survival analysis was used to indicate variables of interest for Cox proportional hazards regression analysis. A model clustered by individual patient to control for inter-eye or inter-graft dependence was constructed to identify variables best predicting penetrating corneal graft failure. RESULTS: Probability of corneal graft survival was 0.86 at 1 year, 0.73 at 5 years, 0.62 at 10 years, and 0.55 at 15 years. Graft survival did not improve over a 15-year timeframe. Variables predicting graft failure in multivariate analysis included transplant centre, donor age, preoperative diagnosis, number of previous ipsilateral grafts, lens status, history of corneal neovascularisation, ocular inflammation or raised intraocular pressure in the grafted eye, requirement for anterior vitrectomy, graft size, early suture removal, postoperative events including graft neovascularisation, rise in intraocular pressure, and rejection episodes, type of treatment for raised intraocular pressure, and arrangements for recipient follow-up. A further 11 variables showing a significant influence on graft survival in univariate analysis were not included in the final Cox model. CONCLUSION: The long-term results of corneal transplantation are no better than for other forms of transplantation and have shown no measurable improvement over the past 15 years.

Corneal Transplantation↗