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Evi-1 expression in Xenopus.

Paul E Mead·Evan Parganas·Shiro Ohtsuka·Kazuhiro Morishita·Laura Gamer·Emin Kuliyev·Christopher V E Wright·James N Ihle
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Abstract

The Evi-1 gene was first identified as a site for viral integration in murine myeloid leukemia. Evi-1 is a zinc finger transcription factor that has been implicated in the development of myeloid neoplasia. In humans, disruption of the Evi-1 locus, by chromosomal rearrangements, is associated with myeloid leukemia and myelodyplastic syndromes. Here, we report the cloning and developmental pattern of expression of Xenopus Evi-1. xEvi-1 is expressed during oogenesis and during embryonic development. In situ hydridization reveals that xEvi-1 has a dynamic expression profile during early embryonic development. Expression of Evi-1 is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck.

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Amino Acid SequenceAnimalsBlotting, NorthernBrainCloning, MolecularDNA, ComplementaryDNA-Binding ProteinsGene Expression Regulation, DevelopmentalGene LibraryIn Situ HybridizationKidneyMDS1 and EVI1 Complex Locus ProteinMiceMolecular Sequence DataNeural CrestOocytesPoly AProto-OncogenesSequence Homology, Amino AcidTime FactorsTranscription FactorsTranscription, GeneticXenopus laevisJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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BibTeXRIS

Paul E Mead, Evan Parganas, Shiro Ohtsuka, Kazuhiro Morishita, Laura Gamer, Emin Kuliyev, Christopher V E Wright, James N Ihle. 2005. Evi-1 expression in Xenopus.. https://doi.org/10.1016/j.modgep.2005.03.007

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