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Double feature at the signalplex.

Kim A Neve
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Abstract

In this issue of Molecular Pharmacology, Oliveras-Reyes et al. (p. 356) describe the agonist-stimulated formation of a caveolin-dependent signalplex that includes both the angiotensin AT(1) receptor and the epidermal growth factor receptor, and probably also a number of other signal transduction intermediates. The signalplex is thought to facilitate the action of protein kinases that mediate angiotensin II-induced transactivation of the epidermal growth factor receptor and activation of extracellular signal-regulated kinase, and epidermal growth factor-induced inositol phosphate accumulation and phosphorylation/desensitization of the AT(1) receptor. This work contributes to an emerging view of the complexity and nonlinearity of signaling via G protein-coupled receptors and receptor tyrosine kinases, and of the importance of membrane compartmentalization to signal transduction.

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AnimalsCaveolinsErbB ReceptorsHumansReceptor, Angiotensin, Type 1Signal TransductionJournal ArticleReviewComment

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Kim A Neve. 2005-05-27. Double feature at the signalplex.. https://doi.org/10.1124/mol.105.015263

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