[Fibrin-depolymerization activity and the antiplatelet effect of small cyclic and linear proline-containing peptides].

V E Pastorova; L A Liapina; I P Alshmarin; P U Ostrovskaia; T A Gudasheva; E V Lugovskoĭ

PubMed · 15926323

[Fibrin-depolymerization activity and the antiplatelet effect of small cyclic and linear proline-containing peptides].

V E Pastorova·L A Liapina·I P Alshmarin·P U Ostrovskaia·T A Gudasheva·E V Lugovskoĭ

Abstract

In our study of the effect of proline-containing linear di- and tri-peptides (Pro-Gly, Pro-Gly-Pro) and cyclic peptide cPro-Gly in vitro, we have found that they show depolymerizing activity towards the nonstabilized form of fibrin in the presence and in the absence of sigma-aminocapronic acid, an inhibitor of enzymatic fibrinolysis. The peptides have an inhibitory effect on platelet aggregation in platelet-enriched blood plasma, when the process is induced by ADP, they also diminish the activity of factor XIIIa in blood plasma.

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Animals Blood Platelets Dipeptides Fibrin Fibrinolytic Agents Oligopeptides Peptides, Cyclic Platelet Aggregation Platelet Aggregation Inhibitors Proline Rats Comparative Study Journal Article

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V E Pastorova, L A Liapina, I P Alshmarin, P U Ostrovskaia, T A Gudasheva, E V Lugovskoĭ. [Fibrin-depolymerization activity and the antiplatelet effect of small cyclic and linear proline-containing peptides].. https://pubmed.ncbi.nlm.nih.gov/15926323/

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