Foxl2 is required for commitment to ovary differentiation.

Chris Ottolenghi; Shakib Omari; J Elias Garcia-Ortiz; Manuela Uda; Laura Crisponi; Antonino Forabosco; Giuseppe Pilia; David Schlessinger

doi:10.1093/hmg/ddi210

PubMed · 15944199

Foxl2 is required for commitment to ovary differentiation.

Chris Ottolenghi·Shakib Omari·J Elias Garcia-Ortiz·Manuela Uda·Laura Crisponi·Antonino Forabosco·Giuseppe Pilia·David Schlessinger

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Abstract

Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 action thus represses the male gene pathway at several stages of female gonadal differentiation. This suggests the possible continued involvement of sex-determining genes in maintaining ovarian function throughout female reproductive life.

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Animals Female Forkhead Box Protein L2 Forkhead Transcription Factors Immunohistochemistry Mice Microscopy, Electron Ovary Sex Differentiation Journal Article Research Support, Non-U.S. Gov't

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Chris Ottolenghi, Shakib Omari, J Elias Garcia-Ortiz, Manuela Uda, Laura Crisponi, Antonino Forabosco, Giuseppe Pilia, David Schlessinger. 2005-06-08. Foxl2 is required for commitment to ovary differentiation.. https://doi.org/10.1093/hmg%2Fddi210

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