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From Poisson distribution to interleukins.

L Aarden
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Abstract

Abstract In the mid-1970s, Ivan Lefkovits and co-workers introduced limiting dilution analysis of T and B cells as a method to quantify antigen-specific T and B cells. In this study, I describe how my co-operation with Ivan on the subject led not only to heated discussions on the validity of the approach but also to the identification of interleukin-2 as T-cell-derived factor, capable of replacing T-cell help required for the activation of B cells.

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AnimalsCell Culture TechniquesCzechoslovakiaHistory, 20th CenturyHumansInterleukin-2Poisson DistributionBiographyHistorical ArticleJournal Article

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L Aarden. 2005. From Poisson distribution to interleukins.. https://doi.org/10.1111/j.1365-3083.2005.01605.x

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