Getting RIP'd Stunts Your Growth.

Claire Ceni; Philip A Barker

doi:10.1016/j.neuron.2005.06.002

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Getting RIP'd Stunts Your Growth.

Claire Ceni·Philip A Barker

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Abstract

The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RIP) of p75NTR and find that p75NTR cleavage is required for MAG-induced RhoA activation and growth inhibition.

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Animals Models, Biological Myelin-Associated Glycoprotein Neurites Neurons Protein Structure, Tertiary rhoA GTP-Binding Protein Comment Journal Article

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Claire Ceni, Philip A Barker. 2005-06-16. Getting RIP'd Stunts Your Growth.. https://doi.org/10.1016/j.neuron.2005.06.002

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