[NP-detecting DNA technologies: solving problems of applied biochemistry].

I N Krakhmaleva; S S Shishkin; N I Shakhovskaia; E B Stoliarova; A G Plugov; A I Kniazev; V G Khomenkov; A B Shevelev; N N Chernov

PubMed · 15977791

[NP-detecting DNA technologies: solving problems of applied biochemistry].

I N Krakhmaleva·S S Shishkin·N I Shakhovskaia·E B Stoliarova·A G Plugov·A I Kniazev·V G Khomenkov·A B Shevelev·N N Chernov

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Abstract

Heterozygosity of CANP3, ACTN3, and GHR genes in specialized collections was studied using state-of-the-art DNA technologies for DNA analysis. A new dinucleotide deletion (AC) at the beginning of exon 21 was identified in five individuals with heterozygous CANP3 gene. Analysis of polymorphism (SNP1747 C-->T) of ACTN3 gene demonstrated a positive association of allele C with a high muscular performance. Real-time PCR assay of SNP1630 (A-->C) in GHR gene suggested a putative negative association of allele C of this SNP with a high muscular performance.

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Actinin Alleles Base Sequence Calpain Carrier Proteins Gene Frequency Heterozygote Humans Isoenzymes Molecular Sequence Data Muscle Proteins Muscle, Skeletal Polymorphism, Single Nucleotide Sequence Deletion Journal Article

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I N Krakhmaleva, S S Shishkin, N I Shakhovskaia, E B Stoliarova, A G Plugov, A I Kniazev, V G Khomenkov, A B Shevelev, N N Chernov. [NP-detecting DNA technologies: solving problems of applied biochemistry].. https://pubmed.ncbi.nlm.nih.gov/15977791/

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