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ACTN3: A genetic influence on muscle function and athletic performance.

Daniel G MacArthur·Kathryn N North
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Abstract

A common variant of the ACTN3 gene, R577X, results in complete deficiency of the alpha-actinin-3 protein in the fast skeletal muscle fibers of more than a billion humans worldwide. We review the evidence that this genetic variant is strongly associated with elite athlete status and with normal variation in human muscle strength and sprinting speed.

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Daniel G MacArthur, Kathryn N North. 2007. ACTN3: A genetic influence on muscle function and athletic performance.. https://doi.org/10.1097/jes.0b013e31802d8874

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