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PubMed · 16009642

Fetal transabdominal pulse oximeter studies using a hypoxic sheep model.

Shoko Nioka·Meltem Izzetoglu·Theresa Mawn·Michael J Nijland·David Boas·Britton Chance
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Abstract

OBJECTIVE: This study investigates the validity of transabdominal pulse oximetry using a sheep fetal hypoxia model with fetal arterial hemoglobin saturation. METHODS: Four pregnant ewes were anaesthetized and cannulated through the brachial artery to measure direct arterial blood saturation, SaO(2). Next, the transabdominal pulse oximeter was used to measure indirect measurement of the arterial saturation of the fetus, SpO(2), from the maternal abdomen. Hypoxia was induced by a balloon placed in the maternal aorta. RESULTS: There is a linear relationship between SaO(2), arterial blood saturation values of the fetus, and SpO(2), the values measured by the transabdominal pulse oximetry with a slope of 0.75 (r(2)=0.76). CONCLUSION: This information can be used to calibrate the transabdominal pulse oximeter as a measurement of fetal arterial saturation. With these results, we can advance the accurate, no-risk, noninvasive transabdominal fetal pulse oximeter for human use. This research may contribute to the more accurate diagnosis of the diseases of the fetus including Hypoxic Ischemic Encephalopathy.

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AbdomenAnimalsDisease Models, AnimalFemaleFetal BloodFetal DiseasesFetal HypoxiaKineticsOximetryPregnancySheepJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S.

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Shoko Nioka, Meltem Izzetoglu, Theresa Mawn, Michael J Nijland, David Boas, Britton Chance. 2005. Fetal transabdominal pulse oximeter studies using a hypoxic sheep model.. https://doi.org/10.1080/14767050500123657

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