Miniaturized detection technology in molecular diagnostics.

Larry J Kricka; Jason Y Park; Sam F Y Li; Paolo Fortina

doi:10.1586/14737159.5.4.549

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Miniaturized detection technology in molecular diagnostics.

Larry J Kricka·Jason Y Park·Sam F Y Li·Paolo Fortina

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Abstract

Miniaturization of genetic tests represents the convergence of molecular biology and engineering and is leading to a new class of small analyzers and test systems for genetic testing with improved analytical characteristics. Miniaturization initially focused on devices that contained micrometer-sized features designed for a particular analytical purpose (e.g., filters for cell isolation and chips for capillary electrophoresis). Now, the focus is shifting to analytical applications based on nano-sized objects such as nanotubes, nanochannels, nanoparticles, nanopores and nanocapacitors. These nanofabricated objects provide new tools for sequencing of nucleic acids and rapid, multiplexed, nucleic acid detection.

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Animals Electrochemistry Electrophoresis, Capillary Humans Microarray Analysis Miniaturization Molecular Diagnostic Techniques Nucleic Acids Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.Review

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Larry J Kricka, Jason Y Park, Sam F Y Li, Paolo Fortina. 2005. Miniaturized detection technology in molecular diagnostics.. https://doi.org/10.1586/14737159.5.4.549

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