A collaborative study of the EDNAP group regarding Y-chromosome binary polymorphism analysis.

María Brion; Berit M Dupuy; Marielle Heinrich; Carsten Hohoff; Bernardette Hoste; Bertrand Ludes; Bente Mevag; Niels Morling; Harald Niederstätter; Walther Parson; Juan Sanchez; Klaus Bender; Nathalie Siebert; Catherine Thacker; Conceiçao Vide; Angel Carracedo

doi:10.1016/j.forsciint.2005.06.002

PubMed · 16024201

A collaborative study of the EDNAP group regarding Y-chromosome binary polymorphism analysis.

María Brion·Berit M Dupuy·Marielle Heinrich·Carsten Hohoff·Bernardette Hoste·Bertrand Ludes·Bente Mevag·Niels Morling·Harald Niederstätter·Walther Parson·Juan Sanchez·Klaus Bender·Nathalie Siebert·Catherine Thacker·Conceiçao Vide·Angel Carracedo

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Abstract

A collaborative study was carried out by the European DNA Profiling Group (EDNAP) in order to evaluate the performance of Y-chromosome binary polymorphism analysis in different European laboratories. Four blood samples were sent to the laboratories, to be analysed for 11 Y-chromosome single nucleotide polymorphisms (SNPs): SRY-1532, M40, M35, M213, M9, 92R7, M17, P25, M18, M153 and M167. All the labs were also asked to submit a population study including these markers. All participating laboratories reported the same results, indicating the reproducibility and robustness of Y-chromosome SNP typing. A total of 535 samples from six different European populations were also analysed. In Galicia (NW Spain) and Belgium, the most frequent haplogroup was R1b*(xR1b1,R1b3df). Haplogroup F*(xK) is one of the most frequent in Austria and Denmark, while the lowest frequency appear in Belgium. Haplogroup frequencies found in this collaborative study were compared with previously published European Y-chromosome haplogroup data.

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Chromosomes, Human, Y DNA Fingerprinting Europe Genetic Markers Genetics, Population Haplotypes Humans Male Polymerase Chain Reaction Polymorphism, Single Nucleotide Reproducibility of Results Journal Article Multicenter Study Research Support, Non-U.S. Gov't

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María Brion, Berit M Dupuy, Marielle Heinrich, Carsten Hohoff, Bernardette Hoste, Bertrand Ludes, Bente Mevag, Niels Morling, Harald Niederstätter, Walther Parson, Juan Sanchez, Klaus Bender, Nathalie Siebert, Catherine Thacker, Conceiçao Vide, Angel Carracedo. 2005-10-29. A collaborative study of the EDNAP group regarding Y-chromosome binary polymorphism analysis.. https://doi.org/10.1016/j.forsciint.2005.06.002

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