Decoding Ca2+ signals: a question of timing.

Shmuel Muallem

doi:10.1083/jcb.200506047

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Decoding Ca2+ signals: a question of timing.

Shmuel Muallem

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Abstract

Receptor-stimulated Ca2+ signals come in several flavors. The Ca2+ signals can be decoded linearly or by integration of the response. How the duration of the signal conveyed by cytosolic Ca2+ concentration ([Ca2+]i) changes is regulated is not well understood. Liu et al. (Liu, Q., S.A. Walker, D. Gao, J.A. Taylor, Y.-F. Dai, R.S. Arkell, M.D. Bootman, H.L. Roderick, P.J. Cullen, and P.J. Lockyer. 2005. J. Cell Biol. 170:183-190) now report an example of decoding based on the differential regulation of Ras function by two Ca2+-sensitive Ras inhibitors: Ca2+-promoted Ras activator (CAPRI), which extends the duration of the effect of Ca2+ on Ras activity, and Ras GTPase activating-like protein (RASAL), which functions as a linear decoder of the Ca2+ signal.

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Amino Acid Sequence Animals Calcium Signaling Cell Membrane Genes, ras Humans Molecular Sequence Data Protein Structure, Tertiary Protein Transport Second Messenger Systems ras GTPase-Activating Proteins ras Proteins Comment Journal Article

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Shmuel Muallem. 2005-07-18. Decoding Ca2+ signals: a question of timing.. https://doi.org/10.1083/jcb.200506047

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